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Cell Stem Cell. 2007 Nov;1(5):497-501.

Evaluating therapeutic efficacy against cancer stem cells: new challenges posed by a new paradigm.

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  • Division of Cell and Molecular Biology, Toronto General Research Institute, Toronto, ON M5G 1L7, Canada. jwang@uhnres.utoronto.ca


Current measures of anticancer drug efficacy reflect bulk cell killing and are poorly suited to detect activity against cancer stem cells (CSCs), which sustain tumor growth. The CSC paradigm necessitates a reexamination of methodologies used to evaluate clinical efficacy of anticancer therapies, as well as strategies employed during preclinical drug development.

[PubMed - indexed for MEDLINE]
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