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Int J Dermatol. 2008 Sep;47(9):950-2. doi: 10.1111/j.1365-4632.2008.03663.x.

Antistreptococcal treatment of guttate psoriasis: a controlled study.

Author information

  • 1GATA Teaching Hospital, Department of Dermatology, 81327, Istanbul, Turkey. gatadermdogan@yahoo.com

Abstract

BACKGROUND:

The role of streptococcal infection in the initiation of guttate psoriasis is well-recognized. But the treatment results with oral erythromycin and phenoxymethylpenicillin are conflicting.

OBJECTIVE:

Our purpose was to evaluate the effectiveness of these antibiotics in the treatment of streptococcus associated guttate psoriasis comparing with a control group.

METHODS:

A total of 43 male patients with serologic evidence of a recent streptococcal infection were studied. Their mean age was 21 years (ranged between 19 and 23 years). These 43 patients were randomly allocated into three groups (no treatment group n = 15, erythromycin group n = 14, phenoxymethylpenicillin group n = 14). Both the treatment groups were treated for 14 d. All the groups were followed up for additional 4 weeks.

RESULTS:

There were no statistically significant improvement in any group and among the groups.

CONCLUSION:

There was no statistically significant improvement in streptococcus associated guttate psoriasis with or without a course of oral penicillin or erythromycin.

PMID:
18937661
[PubMed - indexed for MEDLINE]
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