Bioessays. 2008 Nov;30(11-12):1126-37.

Evolutionary plasticity and cancer breakpoints in human chromosome 3.

Source

Evolutionary Genomics Group, Department of Botany and Zoology, University of Stellenbosch, Matieland, South Africa. moreno@ipvgen.unipv.it

Abstract

In this review, we focus on the evolutionary and biomedical aspects of the architecture of human chromosome 3 (HSA3) by analyzing chromosomal regions that have been conserved during the evolutionary process, compared to those that have been involved in the genomic restructuring of different placental lineages. Given that the organization of human chromosome 3 is derived when compared to the ancestral primate karyotype, and is an autosome that is commonly implicated in human tumour formation, we examined the patterns of change and the genomic consequences that have resulted from its complex evolutionary history. The data show four discrete chromosomal regions that are frequently implicated in chromosomal rearrangements (3p25, 3p22, 3p12 and 3q21). These are rich in repetitive elements and are commonly implicated in structural rearrangements that underpin human genomic disorders and neoplasias. Additional Supporting Information may be found in the online version of this article.

PMID:: 18937354; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms

Publication Types

MeSH Terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Comparative cytogenetics of human chromosome 3q21.3 reveals a hot spot for ectopic recombination in hominoid evolution. [Genomics. 2005]
Comparative cytogenetics of human chromosome 3q21.3 reveals a hot spot for ectopic recombination in hominoid evolution.
Yue Y, Grossmann B, Ferguson-Smith M, Yang F, Haaf T. Genomics. 2005 Jan; 85(1):36-47.
Evolutionarily plastic regions at human 3p21.3 coincide with tumor breakpoints identified by the "elimination test". [Genomics. 2005]
Evolutionarily plastic regions at human 3p21.3 coincide with tumor breakpoints identified by the "elimination test".
Darai E, Kost-Alimova M, Kiss H, Kansoul H, Klein G, Imreh S. Genomics. 2005 Jul; 86(1):1-12.
Plasticity of human chromosome 3 during primate evolution. [Genomics. 2004]
Plasticity of human chromosome 3 during primate evolution.
Tsend-Ayush E, Grützner F, Yue Y, Grossmann B, Hänsel U, Sudbrak R, Haaf T. Genomics. 2004 Feb; 83(2):193-202.
Review Rearrangements and chromosomal evolution. [Curr Opin Genet Dev. 2003]
Review Rearrangements and chromosomal evolution.
Sankoff D. Curr Opin Genet Dev. 2003 Dec; 13(6):583-7.
Review Primate chromosome evolution: ancestral karyotypes, marker order and neocentromeres. [Chromosome Res. 2008]
Review Primate chromosome evolution: ancestral karyotypes, marker order and neocentromeres.
Stanyon R, Rocchi M, Capozzi O, Roberto R, Misceo D, Ventura M, Cardone MF, Bigoni F, Archidiacono N. Chromosome Res. 2008; 16(1):17-39.

See reviews... See all...

Cited by 1 PubMed Central article

Comparative genomics reveals birth and death of fragile regions in mammalian evolution. [Genome Biol. 2010]
Comparative genomics reveals birth and death of fragile regions in mammalian evolution.
Alekseyev MA, Pevzner PA. Genome Biol. 2010; 11(11):R117. Epub 2010 Nov 30.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Evolutionary plasticity and cancer breakpoints in human chromosome 3.
Evolutionary plasticity and cancer breakpoints in human chromosome 3.
Bioessays. 2008 Nov ;30(11-12):1126-37.

PubMed
Genetic and biochemical determinants of serum concentrations of monocyte chemoat...
Genetic and biochemical determinants of serum concentrations of monocyte chemoattractant protein-1, a potential neural tube defect risk factor.
Birth Defects Res A Clin Mol Teratol. 2008 Oct ;82(10):736-41.

PubMed
Further evidence for a maternal genetic effect and a sex-influenced effect contr...
Further evidence for a maternal genetic effect and a sex-influenced effect contributing to risk for human neural tube defects.
Birth Defects Res A Clin Mol Teratol. 2008 Oct ;82(10):662-9.

PubMed
Simultaneous quantification of a non-nucleoside reverse transcriptase inhibitor ...
Simultaneous quantification of a non-nucleoside reverse transcriptase inhibitor efavirenz, a nucleoside reverse transcriptase inhibitor emtricitabine and a nucleotide reverse transcriptase inhibitor tenofovir in plasma by liquid chromatography positive ion electrospray tandem mass spectrometry.
Biomed Chromatogr. 2009 Apr ;23(4):371-81.

PubMed
Evaluation of a peritoneal surface disease severity score in patients with colon...
Evaluation of a peritoneal surface disease severity score in patients with colon cancer with peritoneal carcinomatosis.
J Surg Oncol. 2009 Jan 1 ;99(1):9-15.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: