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Clin Exp Hypertens A. 1991;13(3):401-7.

Increased dietary sodium chloride in patients treated with antihypertensive drugs.

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  • 1Hunter Hypertension Research Group, Faculty of Medicine, University of Newcastle, N.S.W., Australia.


Eleven patients on a normal diet with mild to moderate essential hypertension satisfactorily treated with diverse hypotensive agents entered a randomized double-blind cross-over study to evaluate the effect of additional sodium chloride (100 mmol slow sodium) compared with placebo on blood pressure control over a 6 week period. Despite excellent tablet compliance, sodium chloride failed to significantly alter mean supine or erect blood pressure. These findings as well as a review of the relevant literature suggest that excess dietary sodium does not jeopardize blood pressure control in such patients.

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