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Biom J. 2008 Oct;50(5):884-96. doi: 10.1002/bimj.200710472.

A stepdown procedure with feedback for identifying inferiority among three treatments.

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  • 1Department of Industrial Engineering and Management, Yuan Ze University, No. 135 Yuan-Tung Road, Chungli, Taoyuan, Taiwan, R.O.C. chenju.lin@saturn.yzu.edu.tw


This paper considers the problem of identifying which treatments are strictly inferior to the best treatment or treatments in a balanced one-way layout with three treatments, which has important applications in screening trials for new product development. A stepdown procedure is constructed that selects a subset of the treatments containing only treatments that are known to be strictly inferior to the best treatment or treatments. This stepdown procedure uses feedback from the first stage to the second stage that improves its operating characteristics. The advantages accruing from this feedback are demonstrated.

[PubMed - indexed for MEDLINE]
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