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Nat Genet. 2008 Nov;40(11):1300-6. doi: 10.1038/ng.235. Epub 2008 Oct 19.

Structure and function of a transcriptional network activated by the MAPK Hog1.

Author information

  • 1Howard Hughes Medical Institute, Harvard University Faculty of Arts and Sciences Center for Systems Biology, Department of Molecular and Cellular Biology, Cambridge, Massachusetts 02138, USA.

Abstract

Cells regulate gene expression using a complex network of signaling pathways, transcription factors and promoters. To gain insight into the structure and function of these networks, we analyzed gene expression in single- and multiple-mutant strains to build a quantitative model of the Hog1 MAPK-dependent osmotic stress response in budding yeast. Our model reveals that the Hog1 and general stress (Msn2/4) pathways interact, at both the signaling and promoter level, to integrate information and create a context-dependent response. This study lays out a path to identifying and characterizing the role of signal integration and processing in other gene regulatory networks.

PMID:
18931682
[PubMed - indexed for MEDLINE]
PMCID:
PMC2825711
Free PMC Article

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