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Fertil Steril. 2009 Nov;92(5):1674-8. doi: 10.1016/j.fertnstert.2008.08.110. Epub 2008 Oct 18.

Variations in serum müllerian inhibiting substance between white, black, and Hispanic women.

Author information

  • 1Department of Obstetrics and Gynecology, Brooklyn, and Mount Sinai School of Medicine, Maimonides Medical Center, New York, New York 11228, USA. drseifer@genesisfertility.com

Abstract

OBJECTIVE:

To compare serum müllerian inhibiting substance (MIS) levels between white, black, and Hispanic women to determine whether ovarian aging occurs at a different time course for women of different racial groups.

DESIGN:

Longitudinal study of serum MIS levels in women of different race and ethnicity over two different time points.

SETTING:

Women's Interagency HIV Study, a multicenter prospective cohort study.

PATIENT(S):

Serum samples obtained from 809 participants (122 white, 462 black, and 225 Hispanic women).

INTERVENTION(S):

Comparison of serum MIS between women of different race and ethnicity at two time points (median age 37.5 years and 43.3 years).

MAIN OUTCOME MEASURE(S):

Variation in MIS by race and ethnicity over time, controlling for age, body mass index, HIV status, and smoking.

RESULT(S):

Compared with white women, average MIS values were lower among black (25.2% lower) and Hispanic (24.6% lower) women, adjusting for age, body mass index, smoking, and HIV status.

CONCLUSION(S):

There is an independent effect of race and ethnicity on the age-related decline in MIS over time.

PMID:
18930217
[PubMed - indexed for MEDLINE]
PMCID:
PMC3037722
Free PMC Article

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