Source
Division of Endocrinology and Metabolism, Aristotle University of Thessaloniki, AHEPA University Hospital, Thessaloniki, Greece.
Abstract
OBJECTIVE:
To determine the effect of treatment with vitamin D(3) analogue in the parameters of glucose metabolism in obese women with polycystic ovary syndrome (PCOS).
DESIGN:
Observational study.
SETTING:
Obese women with PCOS in an academic research environment.
PATIENT(S):
Fifteen obese women (mean age 28 +/- 1.3 years, mean body mass index 32.55 +/- 0.43) with documented chronic anovulation and hyperandrogenism were recruited into the study.
INTERVENTION(S):
Alphacalcidol (1-alpha-hydroxyvitamin D(3)) was administered orally 1 microg/day for 3 months. All subjects underwent a frequently sampled IV glucose tolerance test after a 10- to 12-hour overnight fast during a spontaneous bleeding episode before and after treatment with alphacalcidol.
MAIN OUTCOME MEASURE(S):
Peripheral insulin resistance and insulin effectiveness were estimated with minimal model.
RESULT(S):
The first phase of insulin secretion was significantly increased after treatment with alphacalcidol. A favorable statistically significant change also was observed in the lipid profile.
CONCLUSION(S):
Treatment with the vitamin D(3) analogue (alphacalcidol) could be of value in the management of PCOS.