Curr Opin Genet Dev. 2008 Dec;18(6):513-20. Epub 2008 Oct 16.

cis-Regulatory networks during development: a view of Drosophila.

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European Molecular Biology Laboratory, Heidelberg, Germany.

Abstract

Understanding how regulatory networks initiate, maintain and synchronise transcriptional states remains a fundamental goal of developmental biology. Complex patterns of spatio-temporal gene expression are generated through the combined inputs of signalling and transcriptional networks converging on cis-regulatory modules (CRMs). Detailed studies in Drosophila, using transgenic reporter assays and mutagenesis analysis, have dissected the regulatory logic of a number of CRMs. These data have recently been complemented by genome-wide maps of transcription factor binding, revealing an unprecedented view of CRM occupancy and network complexity. The synthesis of data for three well-characterised Drosophila developmental networks reveals emerging themes at both a CRM and a cis-regulatory network level.

PMID:: 18929653; [PubMed - indexed for MEDLINE]

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