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Nutr Metab (Lond). 2008 Oct 18;5:27. doi: 10.1186/1743-7075-5-27.

Role of cytochrome P450 in drug interactions.

Author information

  • 1Department of Chemistry, University of Karachi, Karachi-75270, Pakistan. araynezs@gmail.com.

Abstract

Drug-drug interactions have become an important issue in health care. It is now realized that many drug-drug interactions can be explained by alterations in the metabolic enzymes that are present in the liver and other extra-hepatic tissues. Many of the major pharmacokinetic interactions between drugs are due to hepatic cytochrome P450 (P450 or CYP) enzymes being affected by previous administration of other drugs. After coadministration, some drugs act as potent enzyme inducers, whereas others are inhibitors. However, reports of enzyme inhibition are very much more common. Understanding these mechanisms of enzyme inhibition or induction is extremely important in order to give appropriate multiple-drug therapies. In future, it may help to identify individuals at greatest risk of drug interactions and adverse events.

PMID:
18928560
[PubMed]
PMCID:
PMC2584094
Free PMC Article
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