J Invest Dermatol. 2008 Nov;128(11):2571-4.

Notch and melanocytes: diverse outcomes from a single signal.

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Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA.

Abstract

Notch signaling is an evolutionally conserved pathway that serves as a critical regulator of cell fate. From a series of studies, including a report in this issue, researchers have begun to elucidate the critical functions of Notch signaling in the regulation of melanocyte lineage development. With evidence of a recently identified role for Notch signaling in melanomagenesis, characterization of downstream molecular events may offer potential avenues for the development of novel therapeutic strategies.

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J Invest Dermatol. 2008 Nov;128(11):2686-95.

PMID:: 18927539; [PubMed - indexed for MEDLINE]

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Receptors, Notch

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Melanoblasts' proper location and timed differentiation depend on Notch/RBP-J signaling in postnatal hair follicles. [J Invest Dermatol. 2008]
Melanoblasts' proper location and timed differentiation depend on Notch/RBP-J signaling in postnatal hair follicles.
Aubin-Houzelstein G, Djian-Zaouche J, Bernex F, Gadin S, Delmas V, Larue L, Panthier JJ. J Invest Dermatol. 2008 Nov; 128(11):2686-95. Epub 2008 May 8.
Review The many faces of Notch signaling in skin-derived cells. [Pigment Cell Res. 2007]
Review The many faces of Notch signaling in skin-derived cells.
Pinnix CC, Herlyn M. Pigment Cell Res. 2007 Dec; 20(6):458-65.
Notch signaling via Hes1 transcription factor maintains survival of melanoblasts and melanocyte stem cells. [J Cell Biol. 2006]
Notch signaling via Hes1 transcription factor maintains survival of melanoblasts and melanocyte stem cells.
Moriyama M, Osawa M, Mak SS, Ohtsuka T, Yamamoto N, Han H, Delmas V, Kageyama R, Beermann F, Larue L, et al. J Cell Biol. 2006 May 8; 173(3):333-9. Epub 2006 May 1.
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Sustained Notch signaling in progenitors is required for sequential emergence of distinct cell lineages during organogenesis.
Zhu X, Zhang J, Tollkuhn J, Ohsawa R, Bresnick EH, Guillemot F, Kageyama R, Rosenfeld MG. Genes Dev. 2006 Oct 1; 20(19):2739-53.
Review Notch signaling: its role in epidermal homeostasis and in the pathogenesis of skin diseases. [J Dermatol Sci. 2008]
Review Notch signaling: its role in epidermal homeostasis and in the pathogenesis of skin diseases.
Okuyama R, Tagami H, Aiba S. J Dermatol Sci. 2008 Mar; 49(3):187-94. Epub 2007 Jul 10.

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