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J Invest Dermatol. 2008 Nov;128(11):2569-71. doi: 10.1038/jid.2008.283.

A role for Th17 cells in the immunopathogenesis of atopic dermatitis?

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  • 1St. John's Institute of Dermatology, King's College London School of Medicine and NIHR Biomedical Research Centre, London, United Kingdom.

Abstract

Atopic dermatitis (AD) is a common inflammatory skin disease. Both epidermal barrier dysfunction and immunodysregulation are suggested to influence the pathogenesis of AD. AD has been considered a paradigmatic T helper cell (Th) 2-mediated disease, with a switch to a Th1 cell environment during the chronic phase of the disease. Previously unreported findings now suggest a possible role for Th17 cells as well.

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