Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Science. 2008 Oct 17;322(5900):449-52. doi: 10.1126/science.1161550.

Relation between obesity and blunted striatal response to food is moderated by TaqIA A1 allele.

Author information

  • 1Oregon Research Institute, 1715 Franklin Boulevard, Eugene, OR 97403, USA. estice@ori.org .

Abstract

The dorsal striatum plays a role in consummatory food reward, and striatal dopamine receptors are reduced in obese individuals, relative to lean individuals, which suggests that the striatum and dopaminergic signaling in the striatum may contribute to the development of obesity. Thus, we tested whether striatal activation in response to food intake is related to current and future increases in body mass and whether these relations are moderated by the presence of the A1 allele of the TaqIA restriction fragment length polymorphism, which is associated with dopamine D2 receptor (DRD2) gene binding in the striatum and compromised striatal dopamine signaling. Cross-sectional and prospective data from two functional magnetic resonance imaging studies support these hypotheses, which implies that individuals may overeat to compensate for a hypofunctioning dorsal striatum, particularly those with genetic polymorphisms thought to attenuate dopamine signaling in this region.

Comment in

PMID:
18927395
[PubMed - indexed for MEDLINE]
PMCID:
PMC2681095
Free PMC Article

Images from this publication.See all images (4)Free text

Fig 1
Fig 2
Fig 3
Fig 4
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk