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Clin Cancer Res. 2008 Oct 15;14(20):6712-6. doi: 10.1158/1078-0432.CCR-08-0658.

Y chromosome haplotypes and prostate cancer in Sweden.

Author information

  • 1Department of Medical Epidemiology and Biostatistics and Oncologic Center, Karolinska Institutet, Stockholm, Sweden. slindstr@hsph.harvard.edu

Abstract

PURPOSE:

Certain Y-chromosomal lineages have been suggested to predispose individuals to prostate cancer in the Japanese population; in other ethnic groups, however, the importance of the Y chromosome is poorly understood.

EXPERIMENTAL DESIGN:

To assess the possible Y-chromosomal contribution to prostate cancer risk and prognosis, we analyzed five binary Y-chromosomal markers in 1,447 prostate cancer cases and 983 population controls from the Swedish population. Together, these five markers capture the vast majority of chromosome Y haplogroup diversity in the Swedish population. Individual lineages were tested for association with both prostate cancer risk and cancer-specific death. We replicated observed associations in an independent Swedish prostate cancer case-control study comprising 1,452 cases and 779 controls.

RESULTS:

One rare lineage (I1c) was associated with an increased risk of developing prostate cancer [odds ratio (OR), 2.9; 95% confidence interval (CI), 1.4-5.8; P = 0.001]. However, confirmatory analysis of this lineage in the independent case-control study revealed no association with prostate cancer risk (OR, 0.65; 95% CI, 0.4-1.2, P = 0.17). We observed no association between chromosome Y variation and prostate cancer-specific death.

CONCLUSIONS:

This study provides strong evidence against an important role of the Y chromosome in the initiation or outcome of prostate cancer in the Swedish population.

PMID:
18927315
[PubMed - indexed for MEDLINE]
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