Two hypotheses were tested using a novel individual differences approach, which identifies rate-limiting brain regions, that is, brain regions in which variations in neural activity predict variations in behavioral performance. The first hypothesis is that the rate-limiting regions that support the production of lies about oneself (self-related) are partially distinct from those underlying the production of lies about other individuals (other-related). The second hypothesis is that a cingulate-insular-prefrontal network found to be rate-limiting for interference tasks is involved in both types of lies. The results confirmed both hypotheses and supported the utility of this individual differences approach in the study of deception in particular, as well in the study of complex cognitive phenomena more generally.