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Bull Environ Contam Toxicol. 2008 Dec;81(6):531-4. doi: 10.1007/s00128-008-9567-6. Epub 2008 Oct 16.

Toxicity of chiral pesticide Rac-metalaxyl and R-metalaxyl to Daphnia magna.

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  • 1School of Urban Development and Environmental Engineering, Shanghai Second Polytechnic University, Shanghai, China.


Chirality in pesticides has become a challenge because of enantiomers' different toxicities to non-target organisms. Acute and chronic toxicities of Rac-metalaxyl and R-metalaxyl to Daphnia magna were determined and compared. The 48-h LC50 for Rac- and R-metalaxyl to Daphnia magna were 51.5 and 41.9 mg/L. In a 14-day chronic test, the lowest-observed-effective concentration (LOEC) and no-observed-effective concentration (NOEC) of Rac-metalaxyl were 2 and 1 mg/L, respectively, whereas those of R-metalaxyl were 1 and 0.1 mg/L. Body length, days-to-first-brood and number of broods per female were significantly (p < 0.05) affected by R-metalaxyl at >1.0 mg/L, but affected by Rac-metalaxyl at >or=2.0 mg/L.

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