Experimental animals were sensitized to ovalbumin (OVA) by i.p. injections on days −29 and −15 of this protocol followed by a series of aerosol challenges (protocol days −5, −4, and −3) derived from a 1% OVA solution in saline (control animals received saline alone) focusing allergic immune responses to the lung. These inflammatory responses in the lung were maintained throughout the remaining 12 days of the protocol by provoking the mice on days 0, +4, and +9 with a nebulant derived from a 5% OVA solution in saline (again control animals received saline alone). During the aerosol provocation phase of this protocol, the mice received an intravenous (i.v.) injection of B16-F10 melanoma cells (2 ×105) on day 0 of the time-line and lung metastases were assessed in these animals twelve days later (tumor harvest). Variations of this protocol representing the described experiments of this report are shown below the main time-line. Depletion of CD4+ T cells (T cell depletion) was achieved via i.p. administration of the depleting monoclonal antibody GK1.5 on protocol days −7, −1, and +5. Additional groups of mice were treated with the corticosteroid budesonide through intranasal (i.n.) challenges of mice (0.5mg/kg of body weight) during the OVA challenge and provocation phases of the protocol (days −6, −5, −4, −3, −1, +4, and +9).