Format

Send to:

Choose Destination
See comment in PubMed Commons below
Lancet Infect Dis. 2008 Oct;8(10):650-8. doi: 10.1016/S1473-3099(08)70232-9.

Stockpiling prepandemic influenza vaccines: a new cornerstone of pandemic preparedness plans.

Author information

  • 1Microbiology Department, Canterbury Health Laboratories, University of Otago, Christchurch, New Zealand. lance.jennings@cdhb.govt.nz

Abstract

The history of pandemic influenza, along with the evolving epizootic of the highly pathogenic avian influenza A (H5N1) virus and the severity of associated human infections, serve as a warning to the world of the threat of another influenza pandemic. Conservative estimates suggest that up to 350 million people could die and many more would be affected, causing disruption to health-care systems, society, and the world's economy. WHO has encouraged countries to prepare in advance by developing influenza pandemic preparedness plans that involve public-health and pharmaceutical interventions. Vaccination is a cornerstone of these plans; however, a pandemic vaccine cannot be manufactured in advance because the next pandemic virus cannot be predicted. The concepts of vaccine stockpiling and prepandemic vaccination have thus become attractive. Human H5N1 vaccines are currently available and can induce heterotypic immunity. WHO and governments should give urgent consideration to the use of these vaccines for the priming of individuals or communities who would be at greatest risk of infection if an H5N1 influenza pandemic were to emerge.

Comment in

PMID:
18922487
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk