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Mol Cell. 2008 Sep 26;31(6):777-81. doi: 10.1016/j.molcel.2008.09.001.

Phosphoproteomics: unraveling the signaling web.

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  • 1Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Abstract

In recent years, phosphoproteomic technologies have increased our understanding of cellular signaling networks. Here, we frame recent phosphoproteomics-based advances in the context of the DNA damage response and ErbB receptor family signaling and offer a perspective on how the molecular insights arising from the integration of such proteomic approaches might be used for clinical applications.

PMID:
18922462
[PubMed - indexed for MEDLINE]
PMCID:
PMC2754874
Free PMC Article

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