Kidney Int. 2008 Nov;74(9):1109-12.

Quantitative genetics of renal function: tackling complexities of the eGFR phenotype in gene mapping studies.

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Columbia University, Department of Medicine, Division of Nephrology, New York, New York 10033, USA. Kk473@columbia.edu

Abstract

The linkage approach to quantitative traits, such as estimated glomerular filtration rate (eGFR), has been utilized in several recent studies aimed at identification of susceptibility loci. However, the heterogeneity and complex architecture of the eGFR phenotype make the gene mapping efforts inherently difficult. Mottl and colleagues attempt to tackle this problem in their analysis of a unique family-based cohort of American Indians.

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Kidney Int. 2008 Nov;74(9):1185-91.

PMID:: 18854845; [PubMed - indexed for MEDLINE]

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