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Opt Express. 2008 Oct 13;16(21):16410-22.

Retinal pigment epithelium segmentation by polarization sensitive optical coherence tomography.

Author information

  • 1Center for Biomedical Engineering and Physics, Medical University of Vienna, Austria.

Abstract

We present a new method for identifying and segmenting the retinal pigment epithelium (RPE) in polarization sensitive optical coherence tomography (PS-OCT) images of the human retina. Contrary to previous, intensity based segmentation algorithms, our method uses an intrinsic tissue property of the RPE: its depolarizing, or polarization scrambling effect on backscattered light. Two different segmentation algorithms are presented and discussed: a simpler algorithm based on retardation data, and a more sophisticated algorithm based on local variations of the polarization state calculated from averaged Stokes vector elements. By using a state of the art spectral domain PS-OCT instrument, we demonstrate the method in healthy and diseased eyes.

PMID:
18852747
[PubMed - indexed for MEDLINE]
PMCID:
PMC2976032
Free PMC Article

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