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Nat Rev Genet. 2008 Nov;9(11):855-67. doi: 10.1038/nrg2452.

Epistasis--the essential role of gene interactions in the structure and evolution of genetic systems.

Author information

  • Center for Ecology and Evolution, University of Oregon, Eugene, Oregon 97403 USA. pphil@uoregon.edu

Abstract

Epistasis, or interactions between genes, has long been recognized as fundamentally important to understanding the structure and function of genetic pathways and the evolutionary dynamics of complex genetic systems. With the advent of high-throughput functional genomics and the emergence of systems approaches to biology, as well as a new-found ability to pursue the genetic basis of evolution down to specific molecular changes, there is a renewed appreciation both for the importance of studying gene interactions and for addressing these questions in a unified, quantitative manner.

PMID:
18852697
[PubMed - indexed for MEDLINE]
PMCID:
PMC2689140
Free PMC Article

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