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    Phys Rev Lett. 2008 Sep 12;101(11):118104. Epub 2008 Sep 11.

    Exact solution of a model DNA-inversion genetic switch with orientational control.

    Visco P, Allen RJ, Evans MR.

    Source

    SUPA, School of Physics, The University of Edinburgh, Mayfield Road, Edinburgh EH9 3JZ, United Kingdom.

    Abstract

    DNA inversion is an important mechanism by which bacteria and bacteriophage switch reversibly between phenotypic states. In such switches, the orientation of a short DNA element is flipped by a site-specific recombinase enzyme. We propose a simple model for a DNA-inversion switch in which recombinase production is dependent on the switch state (orientational control). Our model is inspired by the fim switch in E. coli. We present an exact analytical solution of the chemical master equation for the model switch, as well as stochastic simulations. Orientational control causes the switch to deviate from Poissonian behavior: the distribution of times in the on state shows a peak and successive flip times are correlated.

    PMID:
    18851337
    [PubMed - indexed for MEDLINE]

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