Format

Send to:

Choose Destination
See comment in PubMed Commons below
Nat Neurosci. 2008 Dec;11(12):1392-401. doi: 10.1038/nn.2220. Epub 2008 Oct 8.

PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice.

Author information

  • 1Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK.

Abstract

Platelet-derived growth factor alpha receptor (PDGFRA)/NG2-expressing glia are distributed throughout the adult CNS. They are descended from oligodendrocyte precursors (OLPs) in the perinatal CNS, but it is not clear whether they continue to generate myelinating oligodendrocytes or other differentiated cells during normal adult life. We followed the fates of adult OLPs in Pdgfra-creER(T2)/Rosa26-YFP double-transgenic mice and found that they generated many myelinating oligodendrocytes during adulthood; >20% of all oligodendrocytes in the adult mouse corpus callosum were generated after 7 weeks of age, raising questions about the function of the late-myelinating axons. OLPs also produced some myelinating cells in the cortex, but the majority of adult-born cortical cells did not appear to myelinate. We found no evidence for astrocyte production in gray or white matter. However, small numbers of projection neurons were generated in the forebrain, especially in the piriform cortex, which is the main target of the olfactory bulb.

PMID:
18849983
[PubMed - indexed for MEDLINE]
PMCID:
PMC3842596
Free PMC Article

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Write to the Help Desk