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J Bacteriol. 2008 Dec;190(24):8244-7. doi: 10.1128/JB.01161-08. Epub 2008 Oct 10.

Oxidant-responsive induction of the suf operon, encoding a Fe-S assembly system, through Fur and IscR in Escherichia coli.

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  • 1School of Biological Sciences, Seoul National University, Kwanak-gu, Seoul 151-742, South Korea.


The suf operon encoding a Fe-S assembly system is induced by peroxides through activators OxyR and IscR in Escherichia coli. For apo-IscR to bind, oxidation-mediated dissociation of Fur is required. Therefore, a peroxide-responsive signal is transduced through OxyR, IscR, and Fur to achieve oxidation-sensitive and maximal induction of this operon.

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