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J Am Chem Soc. 2008 Nov 5;130(44):14468-70. doi: 10.1021/ja8056503. Epub 2008 Oct 11.

Biaryl construction via Ni-catalyzed C-O activation of phenolic carboxylates.

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  • 1Beijing National Laboratory of Molecular Sciences, Peking University, Beijing 100871, China.


Biaryl scaffolds were constructed via Ni-catalyzed aryl C-O activation by avoiding cleavage of the more reactive acyl C-O bond of aryl carboxylates. Now aryl esters, in general, can be successfully employed in cross-coupling reactions for the first time. The substrate scope and synthetic utility of the chemistry were demonstrated by the syntheses of more than 40 biaryls and by constructing complex organic molecules. Water was observed to play an important role in facilitating this transformation.

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