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Chemistry. 2008;14(33):10297-302. doi: 10.1002/chem.200800095.

Disulfide bond creates a small connecting loop in aminoxy peptide backbone.

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  • 1Department of Chemistry, Fudan University, Shanghai, China.

Abstract

Disulfide-bond formation between the side chains of cysteine-cysteine pairs is often critical to the folding behavior, stability, and functionality of proteins. In this paper, we report that sulfur atoms can be introduced into the amide groups of aminoxy peptides to form a novel type of disulfide bridge, which creates a connecting loop in the peptide backbone.

PMID:
18846598
[PubMed - indexed for MEDLINE]
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