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Clin Immunol. 2009 Jan;130(1):27-33. doi: 10.1016/j.clim.2008.08.018. Epub 2008 Oct 8.

The effects of IL-6 on CD4 T cell responses.

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  • 1Department of Medicine/Immunobiology program, Given Medical Building D305, University of Vermont, 89 Beaumont Avenue, Burlington, VT 05405, USA.


Cytokines have long been known to profoundly influence the adaptive immune response by determining CD4 T cell differentiation. Although IL-6 has been initially characterized as a B cell growth factor and inducer of antibody production research from our lab and others has revealed over the last years that IL-6 also plays a significant role in CD4 T cell differentiation. This review highlights the variety of ways in which IL-6 affects CD4 effector functions and how this may contribute to different types of diseases.

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