Exp Cell Res. 2009 May 15;315(9):1549-55. Epub 2008 Sep 25.

Intracellular trafficking of Notch receptors and ligands.

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Unité de Signalisation Moléculaire et Activation Cellulaire, URA 2582, CNRS, Institut Pasteur, 25 rue du Dr. Roux, 75724 Paris Cedex 15, France. christel.brou@pasteur.fr

Abstract

The Notch pathway represents a highly conserved signaling network, which regulates the formation and maintenance of various organ systems along development and during adulthood. Direct cell-cell contacts between ligand- and receptor-expressing cells underlie activation of the Notch pathway. Notch signaling requires endocytosis in both signal emitting and receiving cells. Recent findings on the roles of a number of modulators show that they act either on the maintenance of an active receptor at the membrane, or on the production of active ligand, or on signal transduction after activation.

PMID:: 18845146; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

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Review

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Substances

Receptors, Notch

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Review Endocytosis and intracellular trafficking of Notch and its ligands. [Curr Top Dev Biol. 2010]
Review Endocytosis and intracellular trafficking of Notch and its ligands.
Yamamoto S, Charng WL, Bellen HJ. Curr Top Dev Biol. 2010; 92:165-200.
Review Regulation of Notch signalling by endocytosis and endosomal sorting. [Curr Opin Cell Biol. 2006]
Review Regulation of Notch signalling by endocytosis and endosomal sorting.
Le Borgne R. Curr Opin Cell Biol. 2006 Apr; 18(2):213-22. Epub 2006 Feb 20.
Review The roles of receptor and ligand endocytosis in regulating Notch signaling. [Development. 2005]
Review The roles of receptor and ligand endocytosis in regulating Notch signaling.
Le Borgne R, Bardin A, Schweisguth F. Development. 2005 Apr; 132(8):1751-62.
Review Notch signaling--constantly on the move. [Traffic. 2007]
Review Notch signaling--constantly on the move.
Nichols JT, Miyamoto A, Weinmaster G. Traffic. 2007 Aug; 8(8):959-69. Epub 2007 Jun 5.
Endosomal entry regulates Notch receptor activation in Drosophila melanogaster. [J Cell Biol. 2008]
Endosomal entry regulates Notch receptor activation in Drosophila melanogaster.
Vaccari T, Lu H, Kanwar R, Fortini ME, Bilder D. J Cell Biol. 2008 Feb 25; 180(4):755-62.

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Cited by 5 PubMed Central articles

Review The role of the Notch pathway in healthy and osteoarthritic articular cartilage: from experimental models to ex vivo studies. [Arthritis Res Ther. 2011]
Review The role of the Notch pathway in healthy and osteoarthritic articular cartilage: from experimental models to ex vivo studies.
Sassi N, Laadhar L, Driss M, Kallel-Sellami M, Sellami S, Makni S. Arthritis Res Ther. 2011 Mar 18; 13(2):208. Epub 2011 Mar 18.
The translation initiation factor 3f (eIF3f) exhibits a deubiquitinase activity regulating Notch activation. [PLoS Biol. 2010]
The translation initiation factor 3f (eIF3f) exhibits a deubiquitinase activity regulating Notch activation.
Moretti J, Chastagner P, Gastaldello S, Heuss SF, Dirac AM, Bernards R, Masucci MG, Israël A, Brou C. PLoS Biol. 2010 Nov 23; 8(11):e1000545. Epub 2010 Nov 23.
The vacuolar ATPase is required for physiological as well as pathological activation of the Notch receptor. [Development. 2010]
The vacuolar ATPase is required for physiological as well as pathological activation of the Notch receptor.
Vaccari T, Duchi S, Cortese K, Tacchetti C, Bilder D. Development. 2010 Jun; 137(11):1825-32.

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