Comparative genomics of the neglected human malaria parasite Plasmodium vivax.
Carlton JM,
Adams JH,
Silva JC,
Bidwell SL,
Lorenzi H,
Caler E,
Crabtree J,
Angiuoli SV,
Merino EF,
Amedeo P,
Cheng Q,
Coulson RM,
Crabb BS,
Del Portillo HA,
Essien K,
Feldblyum TV,
Fernandez-Becerra C,
Gilson PR,
Gueye AH,
Guo X,
Kang'a S,
Kooij TW,
Korsinczky M,
Meyer EV,
Nene V,
Paulsen I,
White O,
Ralph SA,
Ren Q,
Sargeant TJ,
Salzberg SL,
Stoeckert CJ,
Sullivan SA,
Yamamoto MM,
Hoffman SL,
Wortman JR,
Gardner MJ,
Galinski MR,
Barnwell JW,
Fraser-Liggett CM.
The Institute for Genomic Research/J. Craig Venter Institute, 9704 Medical Research Drive, Rockville, Maryland 20850, USA. jane.carlton@nyumc.org
The human malaria parasite Plasmodium vivax is responsible for 25-40% of the approximately 515 million annual cases of malaria worldwide. Although seldom fatal, the parasite elicits severe and incapacitating clinical symptoms and often causes relapses months after a primary infection has cleared. Despite its importance as a major human pathogen, P. vivax is little studied because it cannot be propagated continuously in the laboratory except in non-human primates. We sequenced the genome of P. vivax to shed light on its distinctive biological features, and as a means to drive development of new drugs and vaccines. Here we describe the synteny and isochore structure of P. vivax chromosomes, and show that the parasite resembles other malaria parasites in gene content and metabolic potential, but possesses novel gene families and potential alternative invasion pathways not recognized previously. Completion of the P. vivax genome provides the scientific community with a valuable resource that can be used to advance investigation into this neglected species.
PMID: 18843361 [PubMed - indexed for MEDLINE]
PMCID: PMC2651158 [Available on 2009/10/09]