Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Annu Rev Pathol. 2009;4:315-42. doi: 10.1146/annurev.pathol.3.121806.151529.

Drosophila models of neurodegenerative diseases.

Author information

  • 1Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA. bingwei@stanford.edu

Abstract

Neurodegenerative diseases are progressive disorders of the nervous system that affect specific cellular populations in the central and peripheral nervous systems. Although most cases are sporadic, genes associated with familial cases have been identified, thus enabling the development of animal models. Invertebrates such as Drosophila have recently emerged as model systems for studying mechanisms of neurodegeneration in several major neurodegenerative diseases. These models are also excellent in vivo systems for the testing of therapeutic compounds. Genetic studies using these animal models have provided novel insights into the disease process. We anticipate that further exploration of the animal models will further our understanding of mechanisms of neurodegeneration as well as facilitate the development of rational treatments for debilitating degenerative diseases.

PMID:
18842101
[PubMed - indexed for MEDLINE]
PMCID:
PMC3045805
Free PMC Article

Images from this publication.See all images (8)Free text

Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Atypon Icon for PubMed Central
    Loading ...
    Write to the Help Desk