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[Expression and clinical significance of cyclooxygenase-2 in nasal and paranasal sinus carcinoma].

[Article in Chinese]

Author information

  • 1Department of Otolaryngology, the Affiliated Hospital of Guangdong Medical College, Zhanjiang, 524001, China. cuidewei@163.com

Abstract

OBJECTIVE:

To investigate the relationship between the expression of cyclooxygenase-2 (COX-2) and the carcinogenesis and invasive behavior of nasal and paranasal sinus carcinoma (NPSC).

METHOD:

The expression of COX-2 were detected in 69 case NPSC tissues, paracancerous atypical hyperplasia tissue and normal tissue by using immunohistochemical techniques of SP method.

RESULT:

The positive rate of COX-2 in NPSC tissues and atypical hyperplasia tissue and normal tissue was 65.22% and 42.31% and 3.33%, respectively. The positive rate of COX-2 in NPSC tissues was significantly higher than that in normal tissue (P < 0.01), and increased apparently with the lesion progressing from normal to atypical hyperplasia tissue to NPSC tissues, and also correlated with the increasing of tumor (P < 0.05).

CONCLUSION:

COX-2 may play an important role in the carcinogenesis and invasion of NPSC.

PMID:
18841789
[PubMed - indexed for MEDLINE]
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