AAPS J. 2008 Sep;10(3):494-503. Epub 2008 Oct 8.

Surface energy of microcrystalline cellulose determined by capillary intrusion and inverse gas chromatography.

Steele DF, Moreton RC, Staniforth JN, Young PM, Tobyn MJ, Edge S.

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Pharmaceutical Technology Research Group, Department of Pharmacy & Pharmacology, University of Bath, Bath BA2 7AY, UK.

Abstract

Surface energy data for samples of microcrystalline cellulose have been obtained using two techniques: capillary intrusion and inverse gas chromatography. Ten microcrystalline cellulose materials, studied using capillary intrusion, showed significant differences in the measured surface energetics (in terms of total surface energy and the acid-base characteristics of the cellulose surface), with variations noted between the seven different manufacturers who produced the microcrystalline cellulose samples. The surface energy data from capillary intrusion was similar to data obtained using inverse gas chromatography with the column maintained at 44% relative humidity for the three samples of microcrystalline cellulose studied. This suggests that capillary intrusion may be a suitable method to study the surface energy of pharmaceutical samples.

PMID:: 18841480; [PubMed - indexed for MEDLINE]
PMCID:: PMC2761700

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