Display Settings:

Format

Send to:

Choose Destination
Gen Comp Endocrinol. 2009 Mar;161(1):90-6. doi: 10.1016/j.ygcen.2008.09.006. Epub 2008 Sep 23.

Thyroid receptor subtypes: structure and function in fish.

Author information

  • 1Department of Biological Sciences, University of Calgary, 2500 University Dr. N.W. Calgary, Calgary, Alberta, Canada T2N 1N4. enelson@ucalgary.ca

Abstract

Thyroid hormones are important regulators of vertebrate growth and development, and are under the control of the hypothalamic-pituitary-thyroid axis. Nuclear thyroid receptors (TRs), which act as inducible transcription factors, mediate cellular functions of thyroid hormones. The molecular structure of several subtypes of TRs have been elucidated in vertebrate species, including N-terminal truncations as well as C-terminal variations in the domain responsible for binding hormone. In this paper, we review current information on the thyroid receptors studied in the vertebrate species with emphasis on recent findings in goldfish concerning functional significance of the thyroid receptor subtypes.

PMID:
18840444
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk