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    Biochem Biophys Res Commun. 2008 Dec 12;377(2):351-4. Epub 2008 Oct 7.

    9-cis retinoic acid induces retinoid X receptor localized to the mitochondria for mediation of mitochondrial transcription.

    Lin YW, Lien LM, Yeh TS, Wu HM, Liu YL, Hsieh RH.

    Source

    Department of Urology, Taipei Medical University-Wan Fang Hospital, 111, Section 3, Hsing-Long Road, Taipei 116, Taiwan, ROC.

    Abstract

    We previously reported that 9-cis retinoic acid (RA) treatment induced an increase in mitochondrial (mt)DNA transcription. In order to extend these results, we tested various concentrations of 9-cis RA were used to treat 143B cells. Cells with low membrane potential treated with 9-cis RA showed significantly lower amounts of RXRalpha in mitochondria. We also found lower RXRalpha levels in mtDNA-depleted cells. Treating cells with 9-cis RA significantly increased expression of ND1, ND6, and COX I RNA. However, 9-cis RA-treatment did not appear to induce any significant changes in mtDNA copy number or mitochondrial mass. This study represents that 9-cis RA increases mtDNA transcription but not mtDNA replication, and it suggests that the effects of 9-cis RA on mitochondria are mediated by RXR localization to mitochondria. In addition, this is the first report that 9-cis RA regulation of RXR mitochondrial translocation depends on mitochondrial membrane potential and ATP.

    PMID:
    18840407
    [PubMed - indexed for MEDLINE]

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