Format

Send to:

Choose Destination
See comment in PubMed Commons below
Am J Hematol. 2008 Dec;83(12):922-6. doi: 10.1002/ajh.21262.

Expansion of hematopoietic stem/progenitor cells.

Author information

  • 1Department of Pathology, Hebei Medical University, Shijiazhuang, China.

Abstract

Hematopoietic stem/progenitor cells (HSPCs) transplantation is hampered by the low number of stem cells per sample. To tackle this obstacle, several protocols for expansion of HSPCs in vitro are currently in development, such as the use of cytokine cocktails, coculture with mesenchymal stem cells as feeder cells, and cell culture in bioreactors. With the progress in the understanding of the molecular and cellular mechanisms regulating HSPCs maintenance and expansion, more recent approaches have involved transcription regulation, cell cycle regulation, telomerase regulation, and chromatin-modifying agents. The potential clinical application and safety issues relevant to the expanded HSPCs are also discussed in this review.

Copyright 2008 Wiley-Liss, Inc.

PMID:
18839435
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for John Wiley & Sons, Inc.
    Loading ...
    Write to the Help Desk