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Biochim Biophys Acta. 2009 Jan;1788(1):184-93. doi: 10.1016/j.bbamem.2008.09.001. Epub 2008 Sep 12.

Glycosphingolipid behaviour in complex membranes.

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  • 1Center of Excellence on Neurodegenerative Diseases, Department of Medical Chemistry, Biochemistry and Biotechnology, University of Milan, Segrate, Italy. alessandro.prinetti@unimi.it


Glycosphingolipids, due to their tendency to form laterally separated liquid-ordered phases, possess a high potential for the creation of order in biological membranes. The formation of glycosphingolipid-rich domains within the membrane has profound consequences on the membrane organization at different levels, and on the conformational and biological properties of membrane-associated proteins and multimolecular protein complexes. In this review, we will discuss 1) how glycosphingolipids influence the lateral organization of biological membranes; 2) how glycosphingolipids influence the function of membrane-associated proteins.

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