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Org Lett. 2008 Nov 6;10(21):4947-50. doi: 10.1021/ol802021w. Epub 2008 Oct 4.

Sintokamides A to E, chlorinated peptides from the sponge Dysidea sp. that inhibit transactivation of the N-terminus of the androgen receptor in prostate cancer cells.

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  • 1Genome Sciences Centre, B.C. Cancer Agency, 600 West 10th Avenue, Vancouver, BC, Canada V5Z 4E6.


The new chlorinated peptides sintokamides A to E (1-5) have been isolated from specimens of the marine sponge Dysidea sp. collected in Indonesia. Their structures were elucidated by a combination of spectroscopic and single-crystal X-ray diffraction analyses. Sintokamide A (1) is an inhibitor of N-terminus transactivation of the androgen receptor in prostate cancer cells.

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