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Pediatr Infect Dis J. 2008 Nov;27(11):955-7. doi: 10.1097/INF.0b013e31817bf9a9.

Amoxicillin for postexposure inhalational anthrax in pediatrics: rationale for dosing recommendations.

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  • 1Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA.

Abstract

We reviewed information about the safety and plasma pharmacokinetic data for amoxicillin, specifically related to its potential use for postexposure inhalational anthrax. Amoxicillin (45 mg/kg/d) given orally in 3 divided doses to pediatric patients <40 kg should yield an adequate time above the MIC for susceptible Bacillus anthracis (< or =0.5 microg/mL) over most of the dosing interval (75-100%). Doses <45 mg/kg/d and dosing intervals longer than 8 hours should not be used for postexposure inhalational anthrax.

PMID:
18833025
[PubMed - indexed for MEDLINE]
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