Send to

Choose Destination
See comment in PubMed Commons below
Pediatr Infect Dis J. 2008 Nov;27(11):955-7. doi: 10.1097/INF.0b013e31817bf9a9.

Amoxicillin for postexposure inhalational anthrax in pediatrics: rationale for dosing recommendations.

Author information

  • 1Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA.


We reviewed information about the safety and plasma pharmacokinetic data for amoxicillin, specifically related to its potential use for postexposure inhalational anthrax. Amoxicillin (45 mg/kg/d) given orally in 3 divided doses to pediatric patients <40 kg should yield an adequate time above the MIC for susceptible Bacillus anthracis (< or =0.5 microg/mL) over most of the dosing interval (75-100%). Doses <45 mg/kg/d and dosing intervals longer than 8 hours should not be used for postexposure inhalational anthrax.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Lippincott Williams & Wilkins
    Loading ...
    Write to the Help Desk