Antibacterial activity of hydroxyalkenyl salicylic acids from sarcotesta of Ginkgo biloba against vancomycin-resistant Enterococcus

J G Choi; S I Jeong; C S Ku; M Sathishkumar; J J Lee; S P Mun; S M Kim

doi:10.1016/j.fitote.2008.09.001

Antibacterial activity of hydroxyalkenyl salicylic acids from sarcotesta of Ginkgo biloba against vancomycin-resistant Enterococcus

Fitoterapia. 2009 Jan;80(1):18-20. doi: 10.1016/j.fitote.2008.09.001. Epub 2008 Sep 11.

Authors

J G Choi¹, S I Jeong, C S Ku, M Sathishkumar, J J Lee, S P Mun, S M Kim

Affiliation

¹ National Agricultural Products Quality Management Service, Ministry of Agriculture and Forestry, Jeonju 561-823, South Korea.

PMID: 18832017
DOI: 10.1016/j.fitote.2008.09.001

Abstract

A chloroform fraction prepared from the sarcotesta of Ginkgo biloba showed potent inhibitory activity against vancomycin-resistant Enterococcus (VRE). The active compounds were elucidated to be 2-hydroxy-6-(8-pentadecenyl) salicylic acid (1) and 2-hydroxy-6-(10-heptadecenyl) salicylic acid (2) based on their spectral analysis. Compounds 1 and 2 showed significant antibacterial activities against VRE.

MeSH terms

Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / isolation & purification
Anti-Bacterial Agents / pharmacology*
Enterococcus / drug effects*
Ginkgo biloba* / chemistry
Microbial Sensitivity Tests
Molecular Structure
Plant Extracts / pharmacology*
Salicylates / chemistry
Salicylates / isolation & purification
Salicylates / pharmacology*
Seeds
Vancomycin Resistance

Substances

2-hydroxy-6-(10-heptadecenyl)salicylic acid
2-hydroxy-6-(8-pentadecenyl)salicylic acid
Anti-Bacterial Agents
Plant Extracts
Salicylates