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Oral Dis. 2008 Sep;14(6):497-9. doi: 10.1111/j.1601-0825.2007.01407.x.

Prevalence of oral disease among adults with primary HIV infection.

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  • 1Department of Oral and Maxillofacial Surgery, Obafemi Awolowo University, Ile-Ife, Nigeria.

Abstract

OBJECTIVE:

To explore the type and prevalence of oral mucosal lesions among adults with primary HIV infection (PHI) compared with HIV-negative adults at high risk for HIV disease, and in relation to HIV viral load.

METHODS:

We conducted standardized oral examinations to identify specific oral mucosal lesions among adults with PHI, both pre-seroconversion and post- seroconversion-recently infected, compared with HIV-negative adults. We compared the group with oral lesions to those without oral lesions with respect to HIV-RNA load and CD4 + T-cell count.

RESULTS:

Among 115 adults (predominantly men), pseudomembranous candidiasis was the most common oral lesion among those with PHI, and was found in 4% of the 23 participants in pre-seroconversion and in 9% of 69 participants with post-seroconversion recent infection, compared with none found among 23 HIV negatives. Among those with PHI, the median viral load was higher and the median CD4 + T-cell count lower among the 15 participants with an oral lesion of any type than among the 77 participants without oral lesions (P = 0.02 and 0.04, respectively).

CONCLUSION:

This finding suggests that individuals with PHI who have oral lesions may be more likely to transmit HIV because of their higher viral load.

PMID:
18826380
[PubMed - indexed for MEDLINE]
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