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Department of Applied Chemistry, College of Sciences, South China Agricultural University, Guangzhou 510642, China. chunyuanli@scau.edu.cn
The metabolites of a marine streptomyces sp. actinomycete (No. 195-02) were studied and eight compounds were isolated from the fermentation liquid, structures were elucidated by spectroscopy methods as p-hydroxy-benzonitrile (1), 2-methyl-furan-3-carboxylic acid(2), furan-2-carboxylic acid (3), cyclo(Phe-Phe) (4), cyclo(Leu-Ileu) (5), nicotinic acid (6), 2-(1H-indol-3-yl) acetic acid (7) and bis(2-ethylhexyl) phthalate (8). The compounds 1, 3 and 8 were firstly isolated from Streptomyces sp., compounds 4 -7 were firstly found from marine actinomycetes. Coumpouds 4 and 5 evidently inhibited the growth of cancer cell lines hepG2 and hep2 at the concentration of 50 microg/ml.
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