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Trends Plant Sci. 2008 Nov;13(11):589-95. doi: 10.1016/j.tplants.2008.08.006. Epub 2008 Sep 27.

Timing is everything: regulatory overlap in plant cell death.

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  • 1Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK.


Plant development and defence are intimately connected to programmed cell death (PCD). PCD can occur after environmental cues such as pathogen infection, mechanical damage or abiotic stress. However, PCD also constitutes an essential feature of various aspects of growth and development. Despite the differences in stimuli, the subsequent steps leading to programmed cellular death show considerable commonality, reflecting the essential and overlapping roles of individual regulatory components in these processes. These components can function as positive or negative regulators and can have contrasting functions depending on the form of cell death.

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