Trends Biochem Sci. 1991 May;16(5):187-90.

Who's on first? The U1 snRNP-5' splice site interaction and splicing.

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Howard Hughes Medical Institute, Department of Biology, Brandeis University, Waltham, MA 02254.

Abstract

U1 small nuclear ribonucleoprotein (snRNP) is important for pre-mRNA splicing both in yeast (Saccharomyces cerevisiae) and mammalian systems. The RNA component of U1 snRNP, U1 snRNA, interacts by base pairing with pre-mRNA 5' splice sites. This article examines recent evidence suggesting that U1 snRNP is important for an early step in spliceosome assembly rather than a late step that contributes to the specificity of 5' splice-site cleavage.

PMID:: 1882420; [PubMed - indexed for MEDLINE]

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