J Enzyme Inhib Med Chem. 2008 Oct;23(5):686-95.

Side chain modifications of (indol-3-yl)glyoxamides as antitumor agents.

Antoine M, Marchand P, Le Baut G, Czech M, Baasner S, Gunther E.

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Département de Pharmacochimie, Faculté de Pharmacie, Nantes Université, Nantes, France.

Abstract

New series of analogues of N-(pyridin-4-yl)-2-[1-(4-chlorobenzyl)-indol-3-yl]glyoxamide D-24851 were synthesized, characterized and tested for their in vitro anticancer properties. In the first series, an amino acid spacer was introduced in the glyoxamide chain of D-24851. In the second series, the glyoxamide chain was moved to positions 4 and 5 of indole skeleton. These new compounds were tested on four cancer cell lines (KB, SK-OV-3, NCI-H460 and SF-268), with promising activity for the glycine derivative.

PMID:: 18821257; [PubMed - indexed for MEDLINE]

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