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Trends Cell Biol. 2008 Nov;18(11):517-20. doi: 10.1016/j.tcb.2008.08.004. Epub 2008 Sep 24.

Dishevelled links basal body docking and orientation in ciliated epithelial cells.

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  • 1Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305-5324, USA.

Abstract

Some epithelia contain cells with multiple motile cilia that beat in a concerted manner. New tools and experimental systems have facilitated molecular studies of cilium biogenesis and the coordinated planar polarization of cilia that leads to their concerted motility. A recent elegant study using embryonic frog epidermis demonstrates that Dishevelled, a key regulator of both the Wnt-beta-catenin and planar cell polarity pathways, controls both the docking and planar polarization of ciliary basal bodies.

PMID:
18819800
[PubMed - indexed for MEDLINE]
PMCID:
PMC3989925
Free PMC Article

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