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Bull Acad Natl Med. 2008 Feb;192(2):323-31; discussion 331-2.

[Alzheimer's disease: cellular and molecular aspects].

[Article in French]

Author information

  • 1Laboratoire de Pharmacologie Expérimentale, Université catholique de Louvain, FARL 5410, Avenue Hippocrate 54 B-1200 Bruxelles.


Alzheimer's disease is characterized by the presence of neurofibrillary tangles and senile plaque in the brain. Both disorders must be present in order to confirm a clinical diagnosis of Alzheimer's disease. Neurofibrillary tangles contain hyperphosphorylated microtubule-associated protein tau, while senile plaque contains a core of amyloidpeptide derived from its precursor. Phosphorylation of both amyloid precursor protein and tau represents a biochemical link between the two characteristic lesions of Alzheimer's disease.

[PubMed - indexed for MEDLINE]
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