Amyotroph Lateral Scler. 2008 Dec;9(6):321-2.

Is it too soon for mesenchymal stem cell trials in people with ALS?

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Neurology Clinical Trials Unit, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA. ibadayan@partners.org

Abstract

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease affecting primarily the motor neurons. Stem cell therapy is under development as a possible treatment approach. A pilot study of intraspinal injections of mesenchymal stem cells (MSC) was conducted in 9 participants. We review this paper, the rationale, preclinical data and study design.

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Amyotroph Lateral Scler. 2009 Apr;10(2):123-4.

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J Neurol Sci. 2008 Feb 15;265(1-2):78-83.

PMID:: 18819027; [PubMed - indexed for MEDLINE]

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A novel cell transplantation protocol and its application to an ALS mouse model. [Exp Neurol. 2008]
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Cited by 2 PubMed Central articles

Cell-Based Neurorestorotherapy in Amyotrophic Lateral Sclerosis - Scientific Truth should Rely on Facts, but Not Conjecture. [Front Integr Neurosci. 2011]
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Chen L, Xi H, Huang H. Front Integr Neurosci. 2011; 5:83. Epub 2011 Dec 20.
Review Stem cells in human neurodegenerative disorders--time for clinical translation? [J Clin Invest. 2010]
Review Stem cells in human neurodegenerative disorders--time for clinical translation?
Lindvall O, Kokaia Z. J Clin Invest. 2010 Jan; 120(1):29-40.

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