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    Bioorg Med Chem Lett. 2008 Oct 15;18(20):5415-9. Epub 2008 Sep 12.

    Simplified YM-26734 inhibitors of secreted phospholipase A2 group IIA.

    Oslund RC, Cermak N, Verlinde CL, Gelb MH.

    Source

    Department of Chemistry, Campus Box 351700, University of Washington, Seattle, WA 98195, USA.

    Abstract

    Simplified analogs of YM-26734, a known inhibitor of secreted phospholipase A(2) (sPLA(2)) group IIA, were synthesized and found to also display potent inhibition at low nanomolar concentrations. Analogs were based on the didodecanoylphloroglucinol portion of YM-26734 which contains the predicted active site calcium binding group.

    PMID:
    18818074
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2578825
    Free PMC Article

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