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Exerc Sport Sci Rev. 2008 Oct;36(4):179-86. doi: 10.1097/JES.0b013e3181877e13.

Does AMP-activated protein kinase negatively mediate aged fast-twitch skeletal muscle mass?

Author information

  • 1Human Performance Laboratory, 363 Ward Sports Medicine Building, East Carolina University, Greenville, NC 27858, USA. gordonsc@ecu.edu

Abstract

The activity of 5'-adenosine monophosphate (AMP)-activated protein kinase (AMPK), a negative regulator of cell size, is up-regulated with age in resting and overloaded fast-twitch skeletal muscle but not slow-twitch muscle. Here, we provide evidence to support the hypothesis that elevated AMPK activity plays a potentially important integrative role in the age-related atrophy and diminished capacity for growth specific to fast-twitch skeletal muscle.

PMID:
18815486
[PubMed - indexed for MEDLINE]
PMCID:
PMC2659413
Free PMC Article
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